Title of article
Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator
Author/Authors
Yingchun Lu، نويسنده , , Sukumar Sakamuri، نويسنده , , Quin-Zene Chen، نويسنده , , Yen-Fang Keng، نويسنده , , Vladimir Khazak، نويسنده , , Katrin Illgen، نويسنده , , Silke Schabbert، نويسنده , , Lutz Weber، نويسنده , , Sanjay R Menon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
3957
To page
3962
Abstract
A solution phase parallel synthesis approach was undertaken to rapidly explore the structure–activity relationship of an inhibitor of the Ras/Raf protein interaction identified from a small molecule compound library. Evaluation of the MAPK pathway signaling inhibitory activity of the synthesized analogues as well as their antiproliferative activity and ability to inhibit soft agar growth were performed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794715
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