Title of article :
Lysine sulfonamides as novel HIV-protease inhibitors: Nε-disubstituted ureas
Author/Authors :
Brent R. Stranix، نويسنده , , Gilles Sauvé، نويسنده , , Abderrahim Bouzide، نويسنده , , Alexandre Coté، نويسنده , , Guy Sévigny، نويسنده , , Jocelyn Yelle، نويسنده , , Valérie Perron، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of lysine sulfonamide analogues bearing a Nε-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nα-(alkyl)-Nα-(sulfonamides)lysinol using α-amino-caprolactam was developed. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type HIV virus.
Keywords :
e-mail: bstranix@procyonbiopharma.Com , Lysine , Ureas , HIVprotease inhibitors.* Corresponding author at present address: Procyon Biopharma Inc. , Montreal , Qc , fax: +1-514-496-1702 , Canada , H4P 2R2. Tel.: +1-514-496-1735 , 6100 Royalmount
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
