Author/Authors :
Rosa Arienzo، نويسنده , , David E Clark، نويسنده , , Sue Cramp، نويسنده , , Stephen Daly، نويسنده , , Hazel J Dyke، نويسنده , , Peter Lockey، نويسنده , , Dennis Norman، نويسنده , , Alan G Roach، نويسنده , , Keith Stuttle، نويسنده , , Maxine Tomlinson، نويسنده , , Melanie Wong، نويسنده , , Stephen P Wren، نويسنده ,
Abstract :
A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure–activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors.
