Author/Authors :
Martin J. Di Grandi، نويسنده , , Kevin J. Curran، نويسنده , , Gregg Feigelson، نويسنده , , Amar Prashad، نويسنده , , Adma A. Ross، نويسنده , , Robert Visalli، نويسنده , , Jeanette Fairhurst، نويسنده , , Boris Feld، نويسنده , , Jonathan D Bloom، نويسنده ,
Abstract :
The preparation of α-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s<0.1 μM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.
Keywords :
Thiourea , inhibitors , VZV , varicella zoster virus , Novelinhibitors.
