Title of article :
Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator
Author/Authors :
Noah Tu، نويسنده , , J.T Link، نويسنده , , Bryan K. Sorensen، نويسنده , , Maurice Emery، نويسنده , , Marlena Grynfarb، نويسنده , , Annika Goos-Nilsson، نويسنده , , Thao Bach Nguyen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.
Keywords :
Conjugate.* Corresponding author. Tel.: +1-847-935-6806 , fax: +1-847-938-1674 , Glucocorticoid receptor modulator , e-mail: james.link@abbott.com , bile acid
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
