Author/Authors :
Shudong Wang، نويسنده , , Gavin Wood، نويسنده , , Christopher Meades، نويسنده , , Gary Griffiths، نويسنده , , Carol Midgley، نويسنده , , Iain McNae، نويسنده , , Campbell McInnes، نويسنده , , Sian Anderson، نويسنده , , Wayne Jackson، نويسنده , , Mokdad Mezna، نويسنده , , Rhoda Yuill، نويسنده , , Malcolm Walkinshaw، نويسنده , , Peter M Fischer، نويسنده ,
Abstract :
A series of 2-anilino-4-(1H-pyrrol-3-yl)pyrimidines were prepared and evaluated for their ability to inhibit cyclin-dependent kinases (CDKs). A number of analogues were found to be potent CDK2 and CDK4 inhibitors and to exhibit anti-proliferative activity against human tumour cell lines. Structure–activity relationships and biochemical characterization are presented.
Keywords :
e-mail: swang@cyclacel.com , CDKS , inhibitors , SAR , Crystal structures.* Corresponding author. Tel.: +44-1382-206062 , fax: +44-1382-2060-67
