Title of article :
Synthesis and structure–activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists
Author/Authors :
Michele A. Weidner-Wells، نويسنده , , Todd C Henninger، نويسنده , , Stephanie A. Fraga-Spano، نويسنده , , Christine M. Boggs، نويسنده , , Michele Matheis، نويسنده , , David M Ritchie، نويسنده , , Dennis C. Argentieri، نويسنده , , Michael P. Wachter، نويسنده , , Dennis J. Hlasta، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. In addition, one of the compounds exhibits oral activity in a rat adjuvant arthritis model.
Keywords :
inflammation , Diarylisoxazoles.* Corresponding author. Tel.: +1-908-704-5933 , fax: +1-908-203-8109 , e-mail: mwells@prdus.jnj.com , IL-8
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
