• Title of article

    Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue

  • Author/Authors

    Rumiko Shimazawa، نويسنده , , Mika Gochomori، نويسنده , , Ryuichi Shirai، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2004
  • Pages
    4
  • From page
    4339
  • To page
    4342
  • Abstract
    Compounds (6a–e) were synthesized by phosphorylation of hydrophobic perhydroindan derivatives derived from vitamin D3, and were found to show strong inhibitory activity towards dual-specificity phosphatase Cdc25A (IC50=0.7–24.5 μM).
  • Keywords
    Dysidiolide , Dual-specificity phosphatase , Cdc25A , Cdc25B , Enzyme inhibitor.* Corresponding author. Tel.: +81-743-72-6171 , fax: +81-743-72-6179 , e-mail: rshirai@ms.aist-nara.ac.jp
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2004
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    794790

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=794790