Title of article :
Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue
Author/Authors :
Rumiko Shimazawa، نويسنده , , Mika Gochomori، نويسنده , , Ryuichi Shirai، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Compounds (6a–e) were synthesized by phosphorylation of hydrophobic perhydroindan derivatives derived from vitamin D3, and were found to show strong inhibitory activity towards dual-specificity phosphatase Cdc25A (IC50=0.7–24.5 μM).
Keywords :
Dysidiolide , Dual-specificity phosphatase , Cdc25A , Cdc25B , Enzyme inhibitor.* Corresponding author. Tel.: +81-743-72-6171 , fax: +81-743-72-6179 , e-mail: rshirai@ms.aist-nara.ac.jp
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
