Title of article
Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone
Author/Authors
David B. Whitman، نويسنده , , Ben C. Askew، نويسنده , , Le T. Duong، نويسنده , , Carmen Fernandez-Metzler، نويسنده , , Wasyl Halczenko، نويسنده , , George D. Hartman، نويسنده , , John H. Hutchinson، نويسنده , , Chih-Tai Leu، نويسنده , , Thomayant Prueksaritanont، نويسنده , , Gideon A. Rodan، نويسنده , , Sevgi B. Rodan، نويسنده , , Mark E. Duggan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
4411
To page
4415
Abstract
A series of αvβ3 receptor antagonists lacking the amide bond of previously-reported ‘chain-shortened’ compounds is described. Replacement of the lone amide bond with two methylene groups in this series yields more lipophilic compounds that have longer half-lives, lower clearance, and greater oral bioavailability when administered to dogs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794803
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