Title of article
Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target
Author/Authors
Fredik Lehmann، نويسنده , , Saba Haile، نويسنده , , Eva Axen، نويسنده , , Carmen Medina، نويسنده , , Jonas Uppenberg، نويسنده , , Stefan Svensson، نويسنده , , Thomas Lundb?ck، نويسنده , , Lena Rondahl، نويسنده , , Tjeerd Barf، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4445
To page
4448
Abstract
Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.
Keywords
e-mail: tjeerd.barf@biovitrum.com , FABP4.* Corresponding author. Tel.: +46-8-69-73885 , fax: +46-8-69-73914 , A-FABP inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794809
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