Author/Authors :
Piyasena Hewawasam*[1]، نويسنده , , Wenhong Fan، نويسنده , , Deborah A. Cook، نويسنده , , Kimberly S. Newberry، نويسنده , , Christopher G. Boissard، نويسنده , , Valentin K. Gribkoff، نويسنده , , John Starrett، نويسنده , , Nicholas J. Lodge، نويسنده ,
Abstract :
A novel series of 4-aryl-3-(mercapto)quinolin-2-one derivatives was prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. In vivo efficacy has been demonstrated with a selective maxi-K opening relaxant in a rat model of erectile function.
