Title of article :
Anti-HIV activity of some synthetic lignanolides and intermediates
Author/Authors :
Roc??o Sancho، نويسنده , , Manuel Medarde، نويسنده , , Sonsoles S?nchez-Palomino، نويسنده , , Blanca M Madrigal، نويسنده , , José Alcam??، نويسنده , , Eduardo Mu?oz، نويسنده , , Arturo San Feliciano، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
The evaluation of the anti-HIV-1 activity of synthetic lignanolides and their intermediates is reported. The antiviral activity was studied through luciferase-based assays targeting the HIV-1 promoter activation induced by either, the HIV-1 Tat protein or the cellular transcription factor NF-κB, both known as crucial factors in HIV-1 replication. Among the compounds tested, three of them 2, 4 and 13 were further analysed for their anti-HIV-1 activity by recombinant virus assays, showing a suitable profile for development of novel anti-HIV-1 drugs.
Keywords :
Synthetic lignanolides , HIV-1 Tat protein , fax: +34-923-294515(M.M.) , Transcription factor NF-jB.* Corresponding authors. Tel.: +34-923-294528 , HIV-1 promoter activation , tel.: +34-957-218267 , e-mailaddresses: medarde@usal.es , fax: +34-957-218229 (E.M.) , filmuble@uco.es , Anti-HIV-1
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
