Title of article :
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia
Author/Authors :
Jean Jacques Vanden Eynde، نويسنده , , Annie Mayence، نويسنده , , Tien L Huang، نويسنده , , Margaret H. Collins، نويسنده , , Sandra Rebholz، نويسنده , , Peter D Walzer، نويسنده , , Melanie T. Cushion، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.
Keywords :
Linker , pentamidine , e-mail: thuang@xula.edu , Bisbenzamidine , Pneumocystis carinii pneumonia , conformation , fax: +1-504-520-7954 , Electronic effect.* Corresponding author. Tel.: +1-504-520-7603
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
