Title of article
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia
Author/Authors
Jean Jacques Vanden Eynde، نويسنده , , Annie Mayence، نويسنده , , Tien L Huang، نويسنده , , Margaret H. Collins، نويسنده , , Sandra Rebholz، نويسنده , , Peter D Walzer، نويسنده , , Melanie T. Cushion، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4545
To page
4548
Abstract
A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.
Keywords
Linker , pentamidine , e-mail: thuang@xula.edu , Bisbenzamidine , Pneumocystis carinii pneumonia , conformation , fax: +1-504-520-7954 , Electronic effect.* Corresponding author. Tel.: +1-504-520-7603
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794829
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