Title of article :
Synthesis and evaluation of tacrine–E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease
Author/Authors :
Dong Shao، نويسنده , , Chunyan Zou، نويسنده , , Cheng Luo، نويسنده , , Xican Tang، نويسنده , , Yuanchao Li، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Tacrine–E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer’s disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro.
Keywords :
Hybrids , Tacrine–E2020 , Acetylcholinesterase inhibitor , Alzheimer s disease.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
