Title of article
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine–benzimidazole conjugates with remarkable DNA-binding affinity
Author/Authors
Ahmed Kamal، نويسنده , , P. Ramulu، نويسنده , , O. Srinivas، نويسنده , , G. RAMESH، نويسنده , , P. Praveen Kumar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4791
To page
4794
Abstract
Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
Keywords
Pyrrolobenzodiazepine , benzimidazoles , Hoechst-33258 , DNA-binding ability , cytotoxicity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794875
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