Title of article
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors
Author/Authors
Lin Yan، نويسنده , , Jeffrey J. Hale، نويسنده , , Christopher L. Lynch، نويسنده , , Richard Budhu، نويسنده , , Amy Gentry، نويسنده , , Sander G. Mills، نويسنده , , Richard Hajdu، نويسنده , , Carol Ann Keohane، نويسنده , , Mark J. Rosenbach، نويسنده , , James A. Milligan، نويسنده , , Gan-Ju Shei، نويسنده , , Gary Chrebet، نويسنده , , James Bergstrom، نويسنده , , Deborah Card، نويسنده , , Hugh Rosen، نويسنده , , Suzanne M. Mandala، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
4861
To page
4866
Abstract
A series of conformationally constrained 3-(N-alkylamino)propylphosphonic acids were systematically synthesized and their activities as S1P receptor agonists were evaluated. Several pyrrolidine and cyclohexane analogs had S1P receptor profiles comparable to the acyclic lead compound, 3-(N-tetradecylamino)propylphosphonic acid (3), lowered circulating lymphocytes in mice after iv administration and were thus identified as being suitable for further investigations.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794888
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