Title of article
Discovery of orally active prostaglandin D2 receptor antagonists
Author/Authors
Kazuhiko Torisu، نويسنده , , Kaoru Kobayashi، نويسنده , , Maki Iwahashi، نويسنده , , Yoshihiko Nakai، نويسنده , , Takahiro Onoda، نويسنده , , Toshihiko Nagase، نويسنده , , Isamu Sugimoto، نويسنده , , Yutaka Okada، نويسنده , , Ryoji Matsumoto، نويسنده , , Fumio Nanbu، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
4891
To page
4895
Abstract
A series of N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acids were synthesized and evaluated for prostaglandin D2 (DP) receptor affinity and antagonist activity. Some of them exhibited strong receptor binding and were potent in the cAMP formation assays. These antagonists also suppressed allergic inflammatory responses such as the PGD2-induced increase of microvascular permeability. Structure–activity relationship (SAR) data are presented.
Keywords
Antagonist.* Corresponding author. Tel.: +81-75-961-1151 , fax: +81-75-962-9314 , DP receptor , e-mail: torisu@ono.co.jp , Prostaglandin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794894
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