Author/Authors :
Shuli Mao، نويسنده , , Martin Bouygues، نويسنده , , Christopher Welch، نويسنده , , Mirlinda Biba، نويسنده , , Jen Chilenski، نويسنده , , Raymond F. Schinazi، نويسنده , , Dennis C. Liotta، نويسنده ,
Abstract :
The β-d-enantiomer of FDOC (2′,3′-dideoxy-5-fluoro-oxacytidine) exhibits potent anti-HIV-1 activity. It was obtained in optically pure form by employing a tandem kinetic resolution/chiral salt crystallization protocol. In addition, conditions were developed that allowed the unwanted butyrate ester of the l-enantiomer of FDOC to be racemized. This material could then be recycled in future resolutions.
