Author/Authors :
Nan-Horng Lin، نويسنده , , L.E. Wang، نويسنده , , Xilu Wang، نويسنده , , Gary T. Wang، نويسنده , , Jerry Cohen، نويسنده , , Wen-Zhen Gu، نويسنده , , Haiying Zhang، نويسنده , , Saul H. Rosenberg، نويسنده , , Hing L. Sham، نويسنده ,
Abstract :
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogs of the potent FTI, 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 29 that possesses potent enzymatic and cellular activities.
