Title of article
Biaryl guanidine inhibitors of in vitro HCV-IRES activity
Author/Authors
Elizabeth A. Jefferson، نويسنده , , Punit P. Seth، نويسنده , , Dale E. Robinson، نويسنده , , Dana K. Winter، نويسنده , , Alycia Miyaji، نويسنده , , Stephen A. Osgood، نويسنده , , Eric E. Swayze، نويسنده , , Lisa M. Risen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
5139
To page
5143
Abstract
A structure–activity relationship analysis was carried out on a high-throughput small molecule screening lead for HCV-IRES translation inhibition. The study led to the identification of a guanidine-based structure with low μM inhibitory activity.
Keywords
HCV-IRES , HCV , inhibitor , RNA.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794943
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