Title of article :
Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors
Author/Authors :
Samir Yahiaoui، نويسنده , , Christelle Pouget، نويسنده , , Catherine Fagnere، نويسنده , , Yves Champavier، نويسنده , , Gerard Habrioux، نويسنده , , Albert-José Chulia، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase.
Keywords :
4-Triazolylflavans , Aromatase inhibition , Breast cancer.* Corresponding author. Tel.: +33 (0) 555 435 834 , fax: +33 (0) 555 435910 , e-mail: jose.chulia@unilim.fr
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
