• Title of article

    Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors

  • Author/Authors

    Samir Yahiaoui، نويسنده , , Christelle Pouget، نويسنده , , Catherine Fagnere، نويسنده , , Yves Champavier، نويسنده , , Gerard Habrioux، نويسنده , , Albert-José Chulia، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2004
  • Pages
    4
  • From page
    5215
  • To page
    5218
  • Abstract
    Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase.
  • Keywords
    4-Triazolylflavans , Aromatase inhibition , Breast cancer.* Corresponding author. Tel.: +33 (0) 555 435 834 , fax: +33 (0) 555 435910 , e-mail: jose.chulia@unilim.fr
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2004
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    794958

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=794958