Title of article :
Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase
Author/Authors :
Philip Reigan، نويسنده , , Abdul Gbaj، نويسنده , , Edwin Chinje، نويسنده , , Ian J. Stratford، نويسنده , , Kenneth T. Douglas، نويسنده , , Sally Freeman، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase are described. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor. The scheme shows the prodrug of TPI.
Keywords :
Thymidine phosphorylase , Xanthine oxidase , Inhibitor.* Corresponding author. Tel.: +44 (0)161 275 2366 , prodrug , fax: +44 (0)161 275 2396 , e-mail: sally.freeman@man.ac.uk
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
