Title of article
Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor
Author/Authors
Zhengming Chen، نويسنده , , Ellen Davies، نويسنده , , Wendy S. Miller، نويسنده , , Yan-Shen Shan، نويسنده , , Kenneth J. Valenzano، نويسنده , , Donald J. Kyle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
5275
To page
5279
Abstract
Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series.
Keywords
ORL-1 receptor , SAR , CHEMISTRY , design , Structureactivity , Mu agonist.* Corresponding author. E-mail: zhengming_chen@hotmail.com , Mu receptor , agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794969
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