Title of article :
Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor
Author/Authors :
Zhengming Chen، نويسنده , , Ellen Davies، نويسنده , , Wendy S. Miller، نويسنده , , Yan-Shen Shan، نويسنده , , Kenneth J. Valenzano، نويسنده , , Donald J. Kyle، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series.
Keywords :
ORL-1 receptor , SAR , CHEMISTRY , design , Structureactivity , Mu agonist.* Corresponding author. E-mail: zhengming_chen@hotmail.com , Mu receptor , agonist
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
