Title of article
Three new compounds from the plant Lippia alva as inhibitors of chemokine receptor 5 (CCR5)
Author/Authors
Vinod R. Hegde، نويسنده , , Haiyan Pu، نويسنده , , Mahesh Patel، نويسنده , , Pradip R. Das، نويسنده , , Julie Strizki، نويسنده , , Vincent P. Gullo، نويسنده , , Chuan-Chu Chou، نويسنده , , Alexei V. Buevich، نويسنده , , Tze-Ming Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5339
To page
5342
Abstract
The 70% aqueous methanol extract of the Peruvian plant Lippia alva (Verbenaceae) was found to contain three novel compounds, 1, 2, and 3, which were identified as inhibitors of the chemokine receptor CCR5. The structures of 1–3 were established based on extensive NMR studies. Compounds 1–3 inhibited CCR5 receptor signaling as measured by a calcium mobilization assay with IC50 values of 5.5, 6.0, and 7.2 μg/mL, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794982
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