Title of article
Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones
Author/Authors
Binoy Jose، نويسنده , , Yusuke Oniki، نويسنده , , Tamaki Kato، نويسنده , , Norikazu Nishino، نويسنده , , Yuko Sumida، نويسنده , , Minoru Yoshida، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5343
To page
5346
Abstract
Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors. Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents.
Keywords
Histone deacetylase , inhibitor , Cyclic tetrapeptide , Trifluoromethylketone , Pentafluoroethyl ketone.* Corresponding author. Tel./fax: +81936956061 , e-mail: nishino@life.kyutech.ac.jp
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794983
Link To Document