Title of article :
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands
Author/Authors :
Ronald Bernotas، نويسنده , , Steven Lenicek، نويسنده , , Schuyler Antane، نويسنده , , Guo Ming Zhang، نويسنده , , Deborah Smith، نويسنده , , Joseph Coupet، نويسنده , , Boyd Harrison، نويسنده , , Lee E. Schechter، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively.
Keywords :
Serotonin 5-HT6 indoles GPCR.* Corresponding author. Tel.: +1 484 865 2168 , fax: +1 484 8659399 , e-mail: bernotr@wyeth.com
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
