Title of article
Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists
Author/Authors
Bradley Newhouse، نويسنده , , Shelley Allen، نويسنده , , Benjamin Fauber، نويسنده , , Aaron S. Anderson، نويسنده , , C. Todd Eary، نويسنده , , Joshua D. Hansen، نويسنده , , Justin Schiro، نويسنده , , John J. Gaudino، نويسنده , , Ellen Laird، نويسنده , , David Chantry، نويسنده , , Christine Eberhardt، نويسنده , , Laurence E. Burgess، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
5537
To page
5542
Abstract
A series of racemic and chiral, nonracemic lactams that display high binding affinities, functional chemotaxis antagonism, and selectivity toward CCR4 are described. Compound 41, which provides reasonably high blood levels in mice when dosed intraperitoneally, was identified as a useful pharmacological tool to explore the role of CCR4 antagonism in animal models of allergic disease.
Keywords
lactams , CCR4 , Antagonists.* Corresponding author. Tel.: +1 303 381 6686 , fax: +1 303 3816652 , e-mail: lburgess@arraybiopharma.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795019
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