Author/Authors :
Punit P. Seth، نويسنده , , Ray Ranken، نويسنده , , Dale E. Robinson، نويسنده , , Stephen A. Osgood، نويسنده , , Lisa M. Risen، نويسنده , , Elizabeth L. Rodgers، نويسنده , , Michael T. Migawa، نويسنده , , Elizabeth A. Jefferson، نويسنده , , Eric E. Swayze، نويسنده ,
Abstract :
The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.
Keywords :
Aryl urea , Antibacterial , fax: +1 760 6034653 , Broad spectrum.* Corresponding author. Tel.: +1 760 603 2587 , e-mail: pseth@isisph.com
