Author/Authors :
Thomas Doundoulakis، نويسنده , , Alan X. Xiang، نويسنده , , RICARDO LIRA، نويسنده , , Konstantinos A. Agrios، نويسنده , , Stephen E. Webber، نويسنده , , Wes Sisson، نويسنده , , Robert M. Aust، نويسنده , , Amit M. Shah، نويسنده , , Richard E. Showalter، نويسنده , , James R. Appleman، نويسنده , , Klaus B. Simonsen، نويسنده ,
Abstract :
A series of myxopyronin B analogs has been prepared via a convergent synthetic route and were tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against E. coli and S. aureus. The parent lead compound proved to be very sensitive to even small changes. Only the achiral desmethyl myxopyronin B (1a) provided enhanced potency.
Keywords :
DK-2100 Copenhagen , Denmark. E-mail:kbs@dfuni.dk , RNA polymerase , antibiotics , The Danish University of Pharmaceutical Sciences , Medicinal chemistry.* Corresponding author at present address: Department of MedicinalChemistry , Universitetsparken 2
