Title of article :
Synthesis of small molecule CDC25 phosphatases inhibitors
Author/Authors :
Marie-Odile Contour-Galcéra، نويسنده , , Olivier Lavergne، نويسنده , , Marie-Christine Brezak، نويسنده , , Bernard Ducommun، نويسنده , , Grégoire Prévost، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target
Keywords :
Dual specificity phosphatases inhibitor , Cdc25 inhibitor , Antiproliferative agent.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
