Title of article
Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells
Author/Authors
Eun Jung Park، نويسنده , , Hye Young Min، نويسنده , , Yong-Hyun Ahn، نويسنده , , Cheol-Man Bae، نويسنده , , Jae-Ho Pyee، نويسنده , , Sang Kook Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5895
To page
5898
Abstract
A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E2 production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.
Keywords
COX-2 , PGE2 , Pinosylvin , Cancer chemoprevention.* Corresponding author. Tel.: +82 232773023 , fax: +82 232772851 , e-mail: sklee@ewha.ac.kr
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795091
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