Title of article
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases
Author/Authors
K. Shankaran، نويسنده , , Karla L. Donnelly، نويسنده , , Shrenik K. Shah، نويسنده , , Charles G. Caldwell، نويسنده , , Ping Chen، نويسنده , , William K. Hagmann، نويسنده , , Malcolm MacCoss، نويسنده , , John L. Humes، نويسنده , , Stephen G. Pacholok، نويسنده , , Theresa M. Kelly، نويسنده , , Stephan K. Grant، نويسنده , , Kenny K. Wong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
5907
To page
5911
Abstract
A series of 3- and 5-imino analogs from oxazepane, thiazepane, and diazepane was prepared and evaluated as inhibitors of human nitric oxide synthesis (NOS). The most potent iNOS inhibitor was the thiazepane analog 25 (IC50 = 0.19 μM).
Keywords
NOS synthase.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795094
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