Title of article :
Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic
Author/Authors :
Hikoichiro Maegawa، نويسنده , , Tooru Kimura، نويسنده , , Yasuhiro Arii، نويسنده , , Yasuko Matsui، نويسنده , , Soko Kasai، نويسنده , , Yoshio Hayashi، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Towards the development of chemotherapy for the infection by human T-cell leukemia virus type I (HTLV-I), we have established evaluation systems for HTLV-I protease (PR) inhibitors using both recombinant and chemically synthesized HTLV-I PRs. Newly synthesized substrate-based inhibitors containing hydroxymethylcarbonyl (HMC) isostere showed potent anti-HTLV-I PR activity.
Keywords :
Human T-cell leukemia virus type I (HTLV-I) , Adult T-cellleukemia (ATL) , Aspartic protease , inhibitor , Hydroxymethylcarbonyl(HMC) isostere , Chemical ligation.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
