Title of article :
Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents
Author/Authors :
Patrizia Cal?، نويسنده , , Lars N?rum، نويسنده , , Seema Mukhija، نويسنده , , Anders Hjelmencrantz، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported.
Keywords :
Peptide deformylase , e-mail: pca@combio.biz , fax: +45 70222367 , inhibitors , Antibacterial.* Corresponding author. Tel.: +45 70222365
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
