Title of article :
Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles
Author/Authors :
Ali Almasirad، نويسنده , , Sayyed A. Tabatabai، نويسنده , , Mehrdad Faizi، نويسنده , , Abbas Kebriaeezadeh، نويسنده , , Nazila Mehrabi، نويسنده , , Afshin Dalvandi، نويسنده , , Abbas Shafiee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively.
Keywords :
PTZ , fax: +98 21 6461178 , Substituted 1 , MES.* Corresponding author. Tel.: +98 21 6406757 , 3 , anticonvulsant , 4-oxadiazoles , e-mail: ashafiee@ams.ac.ir
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
