Title of article
Novel diarylsulfonylurea derivatives as potent antimitotic agents
Author/Authors
Semi Kim، نويسنده , , Ji Hyun Park، نويسنده , , Sun-Young Koo، نويسنده , , Jung In Kim، نويسنده , , Min-Hyeung Kim، نويسنده , , Ji Eun Kim، نويسنده , , Kiwon Jo، نويسنده , , Hwan Geun Choi، نويسنده , , Sung Bae Lee، نويسنده , , Sang-Hun Jung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
6075
To page
6078
Abstract
A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors.
Keywords
Diarylsulfonylurea , Antimitotic , Tubulin inhibitor , antitumor , MDR.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795129
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