Title of article
The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists
Author/Authors
Aaron Balog، نويسنده , , Mark E. Salvati، نويسنده , , Weifang Shan، نويسنده , , Arvind Mathur، نويسنده , , Leslie W. Leith، نويسنده , , Donna D. Wei، نويسنده , , Ricardo M. Attar، نويسنده , , Jieping Geng، نويسنده , , Cheryl A. Rizzo، نويسنده , , Chihuei Wang، نويسنده , , Stanley R. Krystek، نويسنده , , John S. Tokarski، نويسنده , , John T. Hunt، نويسنده , , Marco Gottardis، نويسنده , , Roberto Weinmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
6107
To page
6111
Abstract
A novel series of [2.2.1]-azahydantoins has been designed and synthesized in an enantiospecific manner. The ability of these compounds to act as antagonists to the androgen receptor was investigated and several were found to have potent activity in vitro.
Keywords
androgen receptor , fax: +1 609 2526804 , e-mail: aaron.balog@bms.com , Hydantoin.* Corresponding author. Tel.: +1 609 252 4632
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795135
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