Title of article
Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity
Author/Authors
Akiko Shimbashi، نويسنده , , Ayako Tsuchiya، نويسنده , , Masaya Imoto، نويسنده , , Shigeru Nishiyama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
61
To page
65
Abstract
The novel naphthalene-type analogues 14 and 18 and the naphthoquinone-type analogues, 8, 9, 15, 16, 19, 21, 22, and 23–28 have been synthesized, and their in vitro Cdc25A phosphatase-inhibitory activity was examined. In assessment of the inhibitory activity, it was revealed that the naphthoquinone core is contributed to the activity, rather than the alkyl side chain.
Keywords
Cell cycle regulation , Dual-specificity phosphatase , Cdc25A phosphatase inhibitor , Naphthoquinone , biological activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795150
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