Author/Authors :
Gerald W. Shipps Jr.، نويسنده , , Yongqi Deng، نويسنده , , Tong Wang، نويسنده , , Janeta Popovici-Muller، نويسنده , , Patrick J. Curran، نويسنده , , Kristin E. Rosner، نويسنده , , Alan B. Cooper، نويسنده , , Viyyoor Girijavallabhan، نويسنده , , Nancy Butkiewicz، نويسنده , , Michael Cable، نويسنده ,
Abstract :
Aminothiazole-based inhibitors designed for HCV polymerase display low micromolar potencies in biochemical assays. These compounds show a stringent preference for a cyclohexyl hydrophobe at the 2-amino position. The composition of these compounds suggests that they may be interacting at a recently discovered allosteric site on the polymerase.
