Title of article
Synthesis of digalactosyl diacylglycerols and their structure–inhibitory activity on human lanosterol synthase
Author/Authors
Rie Tanaka، نويسنده , , Yuichi Sakano، نويسنده , , Akito Nagatsu، نويسنده , , Masaaki Shibuya، نويسنده , , Yutaka Ebizuka، نويسنده , , Yukihiro Goda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
159
To page
162
Abstract
Digalactosyl and monogalactocyl diacylglycerols (DGDG and MGDG), which were identified as anti-hyperlipemia active components in Colocasia esculenta (Taro), were synthesized. The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. DGDG with two myristoyl groups at both sn-1 and sn-2 positions and with an oleoyl group at the sn-1 position showed the most potent activity.
Keywords
Colocasia esculenta , glycolipid , Digalactosyl diacylglycerols , Lanosterol synthase , Cholesterol biosynthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795170
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