Title of article :
Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
Author/Authors :
Sachiko Tsukamoto، نويسنده , , Hiroshi Hirota، نويسنده , , Misako Imachi، نويسنده , , Masahiro Fujimuro، نويسنده , , Hiroyuki Onuki، نويسنده , , Tomihisa Ohta، نويسنده , , Hideyoshi Yokosawa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A new ubiquitin-activating enzyme (E1) inhibitor, himeic acid A, was isolated from a culture of marine-derived fungus, Aspergillus sp. The structure was determined by spectroscopic analysis. The formation of an E1–ubiquitin (Ub) intermediate was 65% inhibited by himeic acid A at the concentration of 50 μM, while two new related compounds, himeic acids B and C, showed little inhibitory activity even at 100 μM.
Keywords :
Ubiquitin-activating enzyme inhibitor , Marine-derived fungus , Aspergillus sp.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
