Author/Authors :
Jagattaran Das، نويسنده , , C.V. Laxman Rao، نويسنده , , T.V.R.S. Sastry، نويسنده , , M. Roshaiah، نويسنده , , P. Gowri Sankar، نويسنده , , Mohammed Abdul Khadeer، نويسنده , , M. Sitaram Kumar، نويسنده , , Arundhuti Mallik، نويسنده , , N. Selvakumar، نويسنده , , Javed Iqbal، نويسنده , , Sanjay Trehan، نويسنده ,
Abstract :
Some novel oxazolidinone derivatives with benzotriazole as pendant have been synthesized and tested for antibacterial activity. Linearly attached benzotriazole derivative showed more potency compared to angular one in vitro. Out of E/Z-isomers of angularly attached derivatives E-isomer was found to be more potent than Z-isomer. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. Finally, thioacetamide analogue of linear compound gave a lead having activity similar to linezolid in vitro.
Keywords :
oxazolidinones , E–Z-isomers , Antibacterial , Positional isomers , benzotriazole
