Title of article
A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core
Author/Authors
Stephen J. Lewis، نويسنده , , Adrian L. Smith، نويسنده , , Joseph G. Neduvelil، نويسنده , , Graeme I. Stevenson، نويسنده , , Matthew J. Lindon، نويسنده , , A. Brian Jones، نويسنده , , Mark S. Shearman، نويسنده , , Dirk Beher، نويسنده , , Earl Clarke، نويسنده , , Jonathan D. Best، نويسنده , , James E. Peachey، نويسنده , , Timothy Harrison، نويسنده , , J. Luis Castro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
373
To page
378
Abstract
A new series of γ-secretase inhibitors was developed from an in-house screening hit based on a benzobicyclo[4.2.1]nonane core. Lead optimisation studies led to the development of a series of potent inhibitors and in vivo efficacy was demonstrated.
Keywords
?-Secretase inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795210
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