Title of article :
IKCa-channel blockers. Part 2: Discovery of cyclohexadienes
Author/Authors :
Klaus Urbahns، نويسنده , , Siegfried Goldmann، نويسنده , , Jochen Krüger، نويسنده , , Ervin Horv?th، نويسنده , , Joachim Schuhmacher، نويسنده , , Rolf Grosser، نويسنده , , Volker Hinz، نويسنده , , Frank Mauler، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Novel cyclohexadienes have been identified as potent and specific IKCa-channel blockers. In this communication we describe their synthesis as well as their chemical and biological properties. A selected derivative is being enriched in rat brain and reduces the infarct volume, intracranial pressure as well as the water content in a rat subdural hematoma model of traumatic brain injury after iv administration.
Keywords :
IKCa channel , Cyclohexadiene , Water content , rat , cerebral infarction , Brain edema , Potassium channel , Subdural hematoma
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
