Title of article :
Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS
Author/Authors :
Nicola Paesano، نويسنده , , Stefania Marzocco، نويسنده , , Caterina Vicidomini، نويسنده , , Carmela Saturnino، نويسنده , , Giuseppina Autore، نويسنده , , Giovanni De Martino، نويسنده , , Gianluca Sbardella، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Novel benzyl- and phenyl-isothioureidic derivatives have been synthesised and evaluated as inhibitors of nitric oxide synthesis, induced in lipopolysaccharide (LPS)-activated J774.A1 macrophage cell line. The most potent iNOS inhibitor resulting was 1-methyl-3-phenyl-S-methyl isothiourea 5l.
Keywords :
Isothioureas , iNOS , nitric oxide
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
