Title of article
Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities
Author/Authors
Axel G. Griesbeck، نويسنده , , Tamer T. El-Idreesy، نويسنده , , Lars-Oliver H?inck، نويسنده , , Johann Lex، نويسنده , , Reto Brun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
595
To page
597
Abstract
A remarkable increase in antimalarial in vitro activity was achieved by integration of spiroadamantane motifs in 6-alkylidene 1,2,4-trioxanes 3a–h via diastereoselective photooxygenation of allylic alcohols and subsequent BF3-catalyzed peroxyacetalization with adamantanone to give the active compounds 3e–h.
Keywords
Peroxides , Antimalarial , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795249
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