Title of article
Pyrrolidinohydroquinazolines––a novel class of CCR3 modulators
Author/Authors
Ralf Anderskewitz، نويسنده , , Rolf Bauer، نويسنده , , Gisela Bodenbach، نويسنده , , Dirk Gester، نويسنده , , Bernd Gramlich، نويسنده , , Gerd Morschh?user، نويسنده , , Franz W. Birke، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
669
To page
673
Abstract
A novel class of CCR3 modulators is described. Starting with lead compound 4a (Ki: 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (Ki: 28 nM), which surprisingly proved to be an agonist.
Keywords
eotaxin , CCR3 , Antagonist , agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795264
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