Title of article :
Pyrrolidinohydroquinazolines––a novel class of CCR3 modulators
Author/Authors :
Ralf Anderskewitz، نويسنده , , Rolf Bauer، نويسنده , , Gisela Bodenbach، نويسنده , , Dirk Gester، نويسنده , , Bernd Gramlich، نويسنده , , Gerd Morschh?user، نويسنده , , Franz W. Birke، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A novel class of CCR3 modulators is described. Starting with lead compound 4a (Ki: 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (Ki: 28 nM), which surprisingly proved to be an agonist.
Keywords :
eotaxin , CCR3 , Antagonist , agonist
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
