Title of article
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
Author/Authors
Craig W. Lindsley، نويسنده , , Zhijian Zhao، نويسنده , , William H. Leister، نويسنده , , Ronald G. Robinson، نويسنده , , Stanley F. Barnett، نويسنده , , Deborah Defeo-Jones، نويسنده , , Raymond E. Jones، نويسنده , , George D. Hartman، نويسنده , , Joel R. Huff، نويسنده , , Hans E. Huber، نويسنده , , Mark E. Duggan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
761
To page
764
Abstract
This letter describes the development of two series of potent and selective allosteric Akt kinase inhibitors that display an unprecedented level of selectivity for either Akt1, Akt2 or both Akt1/Akt2. An iterative analog library synthesis approach quickly provided a highly selective Akt1/Akt2 inhibitor that induces apoptosis in tumor cells and inhibits Akt phosphorylation in vivo.
Keywords
PKB , Akt , Kinase cancer
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795283
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