• Title of article

    Non-peptidic small molecule inhibitors of XIAP

  • Author/Authors

    Cheol-Min Park، نويسنده , , Chaohong Sun، نويسنده , , Edward T. Olejniczak، نويسنده , , Alan E. Wilson، نويسنده , , Robert P. Meadows، نويسنده , , Stephen F. Betz، نويسنده , , Steven W. Elmore، نويسنده , , Stephen W. Fesik، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    5
  • From page
    771
  • To page
    775
  • Abstract
    Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.
  • Keywords
    SMAC mimetics , XIAP inhibitors
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2005
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    795285

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=795285