Title of article :
Non-peptidic small molecule inhibitors of XIAP
Author/Authors :
Cheol-Min Park، نويسنده , , Chaohong Sun، نويسنده , , Edward T. Olejniczak، نويسنده , , Alan E. Wilson، نويسنده , , Robert P. Meadows، نويسنده , , Stephen F. Betz، نويسنده , , Steven W. Elmore، نويسنده , , Stephen W. Fesik، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
5
From page :
771
To page :
775
Abstract :
Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.
Keywords :
SMAC mimetics , XIAP inhibitors
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2005
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
795285
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=795285
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