Title of article
Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies
Author/Authors
Brian J. Lavey، نويسنده , , Joseph A. Kozlowski، نويسنده , , R. William Hipkin، نويسنده , , Waldemar Gonsiorek، نويسنده , , Daniel J. Lundell، نويسنده , , John J. Piwinski، نويسنده , , Satwant Narula، نويسنده , , Charles A. Lunn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
783
To page
786
Abstract
A novel class of cannabinoid CB2 receptor ligands is described. These triaryl bis-sulfones are nanomolar inhibitors of the CB2 receptor and show high selectivity over the cannabinoid CB1 receptor. One example of this new class decreases ligand-induced GTPγS binding to recombinant CB2 cell membranes, identifying the compound as a CB2-selective inverse agonist.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795287
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